AAY NAING,ARCALAS ARLYN,BOWLES OWEN JOSEPH,BUSSENIUS JOERG,CURTIS JEFFRY KIMO,DEFINA STEVEN CHARLES,DUBENKO LARISA,HARRIS JASON R.,JACKSON-UGUETO EILEEN E.,MANALO JEAN-CLAIRE LIMUN,KIM ANGIE INYOUNG,P
申请号：
NZ59655210
公开号：
NZ596552A
申请日:
2010.05.25
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
596552 Disclosed herein are compounds of formula I, wherein the variables are defined in the specification； a method of preparation thereof； and the use thereof for treating a disease wherein the disease is a cancer, such as breast cancer, mantle cell lymphoma, renal cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, NPM/ALK-transformed anaplastic large cell lymphoma, diffuse large B cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervical cancer, non small cell lung carcinoma, small cell lung carcinoma, adenocarcinoma, colon cancer, rectal cancer, gastric carcinoma, hepatocellular carcinoma, melanoma, pancreatic cancer, prostate carcinoma, thyroid carcinoma, anaplastic large cell lymphoma, hemangioma, glioblastoma, or head and neck cancer. Exemplary embodiments of a compound of formula I include the following: 4-(azocan-1-ylcarbonyl)-7-(2-methyl-1H-benzimidazol-6-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine； (2-methyl-1H-benzimidazol-6-yl)-4-{ [4-(4-nitrophenyl)piperazin-lyl]carbonyl} -2,3,4,5-tetrahydro-1,4-benzoxazepine； 1-[4-(4-{ [7-(2-methyl-1H-benzimidazol-6-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]carbonyl} piperazin-1-yl)phenyl]ethanone； 4-{ [4-(furan-2-ylcarbonyl)piperazin-1-yl]carbonyl} -7-(2-methyl-1H-benzimidazol-6-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine； and N-methyl-7-(2-methyl-1H-benzimidazol-6-yl)-N-[(3-methylphenyl)methyl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxamide.
