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NOVEL LIPID TRIPEPTIDIC HYDROGELLING AGENT AND HYDROGEL
专利权人:
发明人:
MIYAJI, NOBUHIDE,宫地伸英,宮地伸英,IWAMA, TAKEHISA,岩间武久,岩間武久,GOTOH, MASAHIRO,後藤雅宏,後藤雅宏,MARUYAMA, TATSUO,丸山达生,丸山達生,KOHDA, DAISUKE,香田大辅,香田大輔
申请号:
TW097125585
公开号:
TWI465554B
申请日:
2008.07.07
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1): (where R 1 represents an aliphatic group having 9 to 21 carbon atoms R 2 , R 3 and R 4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a -(CH 2 ) n -X group, and at least one of R 2 , R 3 and R 4 represents a -(CH 2 ) n -X group n represents the number of 1 to 4 X represents an amino group, a guanidino group, a -CONH 2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.本發明之課題在於提供於酸性至鹼性的液性範圍中以極少量可形成水凝膠之水凝膠化劑以及具有高的環境.生物體適合性及生物分解性之水凝膠。解決此課題之方法為式(1):(式中,R1表示碳原子數9至21的脂肪族基,R2、R3及R4各自獨立地表示氫原子、可有碳原子數1或2的支鏈之碳原子數1至4的烷基、苯基甲基或-(CH2)n-X基,且R2、R3或R4中的至少一個表示-(CH2)n-X基,n表示1至4之數,X表示胺基、胍基、-CONH2基、或可有1至3個氮原子的5員環或6員環或由5員環與6員環所構成的縮合雜環)所示的脂質肽或其鹽所成的水凝膠化劑及水凝膠。
来源网站:
中国工程科技知识中心
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