ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1

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专利权人:

MSD OSS B.V.

发明人:

DULOS, GRADUS, JOHANNES,VAN EENENNAAM, HANS,CARVEN, GREGORY, JOHN

申请号：

NZ58215008

公开号：

NZ582150A

申请日:

2008.06.13

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is an antibody or antibody fragment thereof, comprising: light chain CDRs SEQ ID NOs: 15, 16 and 17 or variants of any said sequences and heavy chain CDRs SEQ ID NOs: 18, 19 and 20 or variants of any said sequences wherein any of said variants may comprise up to three conservatively modified amino acid substitutions. Also disclosed is the use of the antibody in the manufacture of a medicament to increase immune cell activation, treat cancer or treat an infection or infectious disease.

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