Martin Pulé,Leila Mekkaoui,Persis Amrolia,Sara Ghorashian,Anne Kramer,Gordon Cheung
申请号：
US16573854
公开号：
US20200140544A1
申请日:
2019.09.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—；GY-AFSSS (SEQ ID No. 1)； CDR2—；YPGDED (SEQ ID No. 2) CDR3—；SLLYGDYLDY (SEQ ID No. 3)； and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—；SASSSVSYMH (SEQ ID No. 4)； CDR2—；DTSKLAS (SEQ ID No. 5) CDR3—；QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
