PULE, MARTIN,MEKKAOUI, LEILA,AMROLIA, PERSIS,GHORASHIAN, SARA,KRAMER, ANNE,CHEUNG, GORDON
申请号：
CA2978381
公开号：
CA2978381A1
申请日:
2016.03.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1 GYAFSSS (SEQ ID No. 1) CDR2 YPGDED (SEQ ID No. 2) CDR3 SLLYGDYLDY (SEQ ID No. 3) and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1 SASSSVSYMH (SEQ ID No. 4) CDR2 DTSKLAS (SEQ ID No. 5) CDR3 QQWNINPLT (SEQ ID No. 6). There is also provided a cell comprising such a CAR, and the use of such a cell in the treatment of cancer, in particular a B cell malignancy.
