ЭДЕЛЬМАН Джеффри Л. (US),НЕМЕ Алиссар (US),МАЛОУН Томас К. (US)
申请号：
RU2014123472/04
公开号：
RU2014123472A
申请日:
2012.11.09
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, tautomers or pharmaceutically acceptable salts thereof, wherein R is optionally substituted alkyl, optionally substituted C-alkenyl, optionally substituted C-Calkinil, C or optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted benzyl, optionally substituted heterocycle, optionally substituted SCtsikloalkenil optionally substituted C Stsiklodien optionally substituted by O (C-C) alkyl, amino, sulfonamide e groups, amide groups, except fenila.2. A compound according to Claim. 1, characterized in that R soboy3. A compound according to Claim. 1, characterized in that R is substituted aril.4. A compound according to Claim. 1, characterized in that R soboy5. A compound according to Claim. 1 having strukturu6. A compound according to Claim. 1 having strukturu7. A compound according to Claim. 1 having strukturu8. A pharmaceutical composition comprising as active ingredient a therapeutically effective amount of a compound according to Claim. 1 and a pharmaceutically acceptable adjuvant, diluent or nositel.9. A pharmaceutical composition according to claim 8, wherein the compound is selected from:. And10. A method of treating a disorder associated with modulation of the glucocorticoid receptor which comprises administering to a patient in need thereof a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I wherein R is optionally substituted C alkyl, optionally substituted C-alkenyl, optionally substituted C -Salkinil optionally substituted cycloalkyl Seeley, optionally1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, таутомеры или фармацевтически приемлемые соли,где R1 представляет собой необязательно замещенный С7-С11 алкил, необязательно замещенный C2-C8 алкенил, необязательно замещенный C2-C8 алкинил, необязательно замещенный C4 или С6-8 циклоалкил, необязатель
