David A. Stein;Richard K. Bestwick;Patrick L. Iversen;Dwight D. Weller
发明人:
David A. Stein,Richard K. Bestwick,Patrick L. Iversen,Dwight D. Weller
申请号：
US11517757
公开号：
US08524676B2
申请日:
2006.09.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5′ untranslated region identified by SEQ ID NO:7.
