Dan V. Mourich,Hong Mu Moulton,David J. Hinrichs,Patrick L. Iversen
申请号：
US13187338
公开号：
US20120027791A1
申请日:
2011.07.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method and conjugate for selectively killing antigen-activated T cells are disclosed. The conjugate is composed of a substantially uncharged antisense compound targeted against the human cFLIP protein, and a reverse TAT (rTAT) polypeptide coupled covalently to the antisense compound. The rTAT polypeptide is effective to produce selective uptake of the conjugate into antigen-activated T cells, relative to the uptake of the conjugate into non-activated T cells. The cFLIP antisense compound causes activation induced cell death (AICD) of activated lymphocytes. The method is useful in treating transplantation rejection and autoimmune conditions.
