GEORG JAESCHKE,ANTONIO RICCI,DANIEL RUEHER,ERIC VIEIRA,WOLFGANG GUBA,BARBARA BIEMANS
申请号：
ARP140103499
公开号：
AR097721A1
申请日:
2014.09.22
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
This table refers to formula compound (1),That's n or c-r1；G is an aromatic ring or a heteroaromatic ring, containing 0, 1, 2 or 3 heteroatoms. It is composed of N, pyridine, pyridine, pyridine, pyridine, thiophosphor, thiophosphor, PYRAZOLIN, pyrazolidan and other phenyl and pyridine with different positions. It can be replaced by 1, 2 or 3 alternatives selected from the group of halogen, low tar, low oxygen, low oxygen, replaced by halogen or NRR, both R and R are hydrogen or low tar,Or they can form a saturated non periodic group of 5 or 6 elements with N atoms, which may contain additional oxygen, NH or a group below n-1； R1 is hydrogen, halogen or lower tar replaced by halogen； R1 is hydrogen, halogen or lower tar replaced by halogen. 2. Halogen； R2 is hydrogen, low tar, low oxygen tar, cyclopropyl or isocyclopropyl compound, or R2 can form a formula group in group G together with the closest carbon atom, where a is - ch-83222 -；-CH CH o -C (CH) -R3 is phenyl or pyridine, in which case the atoms of pyridine class n may be in different positions； or a salt or salt, racemic mixture or its pair of corresponding isomers and / or optical isomers and / or corresponding stereoisomers acceptable for drugs. It was unexpectedly found that the common formula compound (1) is a positive herring modulator (map) of the glucose-4 metabolite receptor (mGluR4), which can be used to treat Parkinson's disease, anxiety, emesis, obsessive-compulsive disorder, autism, neuroprotection, cancer, Depression and type 2 diabetes.La presente se refiere a compuestos de fórmula (1), en la que: Y es N o C-R¹； G es un anillo aromático o heteroaromático de 5 ó 6 elementos que contiene 0, 1, 2 ó 3 heteroátomos, seleccionado de entre el grupo que consiste de fenilo, piridinilo con diferentes posiciones de N, imidazolilo, pirazinilo, pirimidinilo, tiofenilo, tiazolilo, pirazolilo o tiadiazolilo, que se sustituyen opcionalmente con 1, 2 ó 3 sustituyentes, seleccionados de entre el grupo que consis
