PLANCHER, Jean, Marc,VIEIRA, Eric,JAESCHKE, Georg,BIEMANS, Barbara,O'HARA, Fionn,RUEHER, Daniel,GUBA, Wolfgang,RICCI, Antonio
申请号：
CR20160384
公开号：
CR20160384A
申请日:
2015.02.24
申请国别(地区):
CR
年份:
2016
代理人:
摘要：
1. The invention refers to Formula 1 compound with y as N or c-r1；R1 is hydrogen or F； R1 is hydrogen, halogen or lower tar, replaced by halogen； R2 is hydrogen or lower tar； or R2 and R4 form a multi cycle ring composed of six members, including ch2-ch2-o-ch2-o-ch2-nr-c (or)；R is hydrogen, lower tar, phenyl or benzene； R3 is phenyl or pyridine, in which case, N atoms in the pidan group may be in different positions； R4 is hydrogen, low tar or low-oxygen tar； R4 is hydrogen, low tar, optionally substituted with halogen or low-oxygen phenyl, O is CYCLOPROPYLENE, or alternative pyridine diene, replaced by halogen, low tar, low oxygen or = O, or alternative pyridine diene, replaced by low tar, low oxygen or = O, or 1-Low tar pyridine, or pyridyl, or alternative pyridine diene, or low tar, low oxygen or = O,O is 1-methylpyridinolo [2,3-b] pyridine-5-il, or 6-pyridane [1,2-b] pyridine-6-il； or R4 and R4 together form a heterocyclic ring consisting of 4, 5 or 6 members including (CH2) 5,-CH2-CH2-O-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-O-CH2-CH2- or CH2-CH2-CH2-O-CH2； R5 and R5 are hydrogen or lower alkyl； or R4 together with R5 forms a saturated 5-membered ring containing -CH2-CH2-CH2-；Or for an racemic mixture or its corresponding enantiomers and / or optical isomers and / or stereoisomers, a pharmaceutically acceptable salt or acid additive salt.La presente invención se refiere a compuestos de fórmula I en el que Y es N o C-R1¿； R1¿ es hidrógeno o F； R1 es hidrógeno, halógeno o alquilo inferior sustituido con halógeno； R2 es hidrógeno o alquilo inferior； o R2 forma junto con R4 un anillo heterocíclico de 6 miembros que contiene ¿CH2-CH2-O-CH2- o ¿CH2-CH2-NR-C(O)； R es hidrógeno, alquilo inferior, fenilo o bencilo； R3 es fenilo o piridinilo, en el que el átomo de N en el grupo de piridinilo puede estar en diferentes posiciones； R4¿ es hidrógeno, alquilo inferior o alcoxialquilo inferior； R4 es hidrógeno, alquilo inferior, fenilo opcionalmente sustituido con halógeno
