<;P>;PROBLEM TO BE SOLVED: To provide a nonhuman model animal of diabetes, cardiac failure or the like, usable for the screening of a diabetes-treating agent, a cardiac failure-treating agent or the like. <;P>;SOLUTION: The model animal of the diabetes, the cardiac failure or the like, or a part thereof comprises a knockout nonhuman animal or a part thereof from which the whole or a part of the functions of at least one gene selected from the group consisting of EBI3 gene, IL27-p28 gene and WSX-1 gene is deleted. <;P>;COPYRIGHT: (C)2011,JPO&INPIT