GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;CANCER RESEARCH TECHNOLOGY LTD.
发明人:
ADAMS, Nicholas David,BENOWITZ, Andrew B.,BENEDE, Maria Lourdes Rueda,EVANS, Karen Anderson,FOSBENNER, David T.,KING, Bryan W.,LI, Mei,LUENGO, Juan Ignacio,MILLER, William Henry,REIF, Alexander Joseph
申请号：
PE2018003216
公开号：
PE20190971A1
申请日:
2017.06.13
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
It refers to pyridine (IBBR) compounds, in which X41BBR and X42BBR are CN, methyl, fluorine, chlorine, etc., Y4BBR is S or NH, R41BBR is C1-6 tar, C1-4 tar, N (C1-4 tar) 2, R43BBR is C1-4 tar, phenyl, pyridyl alcohol, etc., and R44BBR and R45BBR are CAD. An H, C1-6, tridiene, R44BBR and R45BBR, together with the nitroglycerin they bind together, can choose from one to three heterosexuals to form a heterosexual. The most popular compounds are 2-[3,5-dioxane-6-(dimethylamine)-4-ethylpyridine-2-liter] thiamide and 2-((3,5-dioxane-4-cyclopentane-6-(1,4-dioxane-1-il) pyridine-2-phenylacetamide).Others He also mentioned a pharmaceutical composer. These compounds are selective inhibitors of methyltransferase-1 (DNMT1) DNA activity and can be used in cancer treatment.SE REFIERE A COMPUESTOS DE PIRIDINA DE FORMULA (IVbbr) DONDE X41bbr Y X42bbr SON CADA UNO CN, METILO, FLUOR, CLORO, ENTRE OTROS； Y4bbr ES S O NH； R41bbr ES ALQUILO C1-6, ALQUILOXI C1-4, N(ALQUILO C1-4)2, ENTRE OTROS； R43bbr ES ALQUILO C1-4, FENILO, PIPERIDINILO, ENTRE OTROS； R44bbr Y R45bbr SON CADA UNO H, ALQUILO C1-6, TRIAZOLILO, ENTRE OTROS； R44bbr Y R45bbr SE TOMAN JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS Y OPCIONALMENTE DE 1 A 3 HETEROATOMOS PARA FORMAR UN HETEROCICLOALQUILO. SON COMPUESTOS PREFERIDOS: 2-{[3,5-DICIANO-6-(DIMETILAMINO)-4-ETILPIRIDIN-2-IL]SULFANIL}-2-FENILACETAMIDA； 2-((3,5-DICIANO-4-CICLOPROPIL-6-(1,4-DIAZEPAN-1-IL)PIRIDIN-2-IL)TIO)-2-FENILACETAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE LA ACTIVIDAD DE ADN METILTRANSFERASA-1 (DNMT1) SIENDO UTILES EN EL TRATAMIENTO DEL CANCER
