REN, PINGDA,LIU, YI,LI, LIANSHENG,CHAN, KATRINA,WILSON, TROY EDWARD,CAMPBELL, SIMON FRASER
申请号：
PE2012000229
公开号：
PE20121148A1
申请日:
2010.08.17
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to a formula compound I, wherein X is O, s, N； W1 is n, C = O, NH, etc.； W2 is n, CH2, C = O, etc.； W3 is n, NH, N - (C1-C6 tar),W4 is n, C = O, Cr6, among which there are no more than two N atoms, no more than two C groups = or adjacent； W5 is n, CR7； W6 is n, CR8； R1 and R2 are h, tar, isotar, ammonium sulfite, cyclopentadiene, isopropene, isopropene, among others； R6, R7 and R8 are h, tar, isotar, alquenilo, CYCLOPROPYLENE, arilo, ariquillo, respectively, Alcoxi and others The preferred compounds are: 5 - (3 - (pyridine-4-il) pyridan-6-il) benzo [D] oxazol-2-amine； 2 - (4 - (8 - (2-aminobenzo [D] oxazol-5-il) - 3-metr-2-oxo-2, 3-dihydro-1h-imidazo [4.5-c] quinolin-1-il) - phenyl) - 2-propane；There are others These compounds are inhibitors of phospho-3-quinase (pi3500 enzyme) for the treatment of asthma, aerosols, cortitis, allergies, allergies, relapses, diabetes, etc.REFERIDA A UN COMPUESTO DE FORMULA I, DONDE X ES O, S, N； W1 ES N, C=O, NH, ENTRE OTROS； W2 ES N, CH2, C=O, ENTRE OTROS； W3 ES N, NH, N-(ALQUILO C1-C6), ENTRE OTROS； W4 ES N, C=O, CR6, ENTRE OTROS； EN DONDE NO MAS DE DOS ATOMOS DE N Y NO MAS DE DOS GRUPOS C=O SON ADYACENTES； W5 ES N, CR7； W6 ES N, CR8； R1 Y R2 SON CADA UNO H, ALQUILO, HETEROALQUILO, ALQUENILO, CICLOALQUILO, HETEROARILO, ENTRE OTROS； R6, R7 Y R8 SON CADA UNO H, ALQUILO, HETEROALQUILO, ALQUENILO, CICLOALQUILO, ARILO, ARILALQUILO, ALCOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(3-(PIRIDIN-4-IL)IMIDAZO[1,2-a]PIRIDIN-6-IL)BENZO[d]OXAZOL-2-AMINA； 2-(4-(8-(2-AMINOBENZO[d]OXAZOL-5-IL)-3-METIL-2-OXO-2,3-DIHIDRO-1H-IMIDAZO[4,5-c]QUINOLIN-1-IL)FENIL)-2-METILPROPANONITRILO； ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFATIDIL INOSITOL-3 QUINASA (PI3 QUINASA) UTILES EN EL TRATAMIENTO DE ASMA, ENFISEMA, PSORIASIS, ALERGIA, ANAFILAXIS, REESTENOSIS, DIABETES, ENTRE OTROS
