The present invention relates to a method for preventing oxidation of an antioxidant material, the material, and a use thereof and, more specifically, to a method for preventing oxidation of an antioxidant material by treating the antioxidant material with aptamer, to an aptamer having such activity, and to an application to various fields, such as medical products, cosmetic products, and food, using the aptamer. The aptamer of the present invention has an effect of preventing oxidation of an antioxidant material, such as vitamin C, and therefor, the aptamer of the present invention can be applied to various fields, such as medical products, cosmetic products, and food, in need of prevention of the oxidation of the antioxidant material.
