Useful for modulating the activity of the kinase regulated in COPD, and Pharmaceutical compositions thereof. In This also provides Methods of use for treating, preventing or ameliorating one or more symptoms of a disorder, disease or condition mediated by RC Kinase.Claim 1: a compound of the formula (1), or a stereoisomer, enantiomer, a mixture of a mixture of enantiomers, Diastereomers, or a variant of that Isotope； or a Salt, solvate, hydrate or a prodrug that acceptable from the point of view of pharmaceutical, Where: r u00b9 is Hydrogen, alkyl c u2081 u208b u2086, alquenilo c u2082 u208b u2086 alquinilo c u2082 u208b u2086 c u2083 u208b u2081 u2080 c u2086 u208b u2081 u2084, cycloalkyl, aryl,Heteroaryl or heterociclilo； R u00b2 is c u2083 u208b u2081 u2080 c u2086 u208b u2081 u2084 cycloalkyl, aryl, heteroaryl or heterociclilo； r u00b3 c u2081 u208b u2086 is Hydrogen, alkyl, cycloalkyl alquenilo c u2082 u208b u2086 alquinilo c u2082 u208b u2086 c u2083 u208b u2081 u2080 c u2086 u208b u2081 u2084, aryl, heteroaryl, heterociclilo, - C (o) r u00b9 u1d43, - C (o) or u00b9 u1d43, Nr u00b9 u1d47r u00b9 u1d9c, - C (o) - C (nr u00b9 u1d43) nr u00b9 u1d47r u00b9 u1d9c, r u00b9 u1d43 - S (o), (OR) u2082r u00b9 u1d43 - S, - s or - S (o) nr u00b9 u1d47r u00b9 u1d9c (OR) is u2082nr u00b9 u1d47r u00b9 u1d9c； r u2074 Ciano, aminocarbonilo,C (OR) n = cr u2074 u1d43r u2074 u1d47 or - C (o) nr u2074 u1d43r u2074 u1d47； where r u2074 u1d43 is c u2081 u208b u2086: rent, alquenilo c u2082 u208b u2086, alquinilo c u2082 u208b u2086 cycloalkyl, aryl or heteroaryl c u2083 u208b u2081 u2080, c u2086 u208b u2081 u2084, heterociclilo； r u2074 u1d47 is independently Hydrogen, alkyl c u2081 u208b u2086, alquenilo c u2082 u208b u2086, ALQUIN ILO c u2082 u208b u2086 c u2083 u208b u2081 u2080 c u2086 u208b u2081 u2084, cycloalkyl, aryl, heteroaryl heterociclilo, r u00b9 u1d43, - C (o) C (o) or u00b9 u1d43, - C (o) - C (nr u00b9 u1d47r u00b9 u1d9c, nr u00b9 u1d47r u00b9 u1d9c nr u00b9 u1d43),
