АХРАБИ Сайех (NO),МЮРЕН Финн (NO),ЭРИКСЕН Оле Хенрик (NO)
申请号：
RU2013105783/15
公开号：
RU2013105783A
申请日:
2011.07.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition comprising as an active ingredient cytarabine derivative of formula (I): wherein R Ryavlyayutsya hydrogen atoms, and R is C- C- or saturated or monounsaturated acyl group, or a pharmaceutically acceptable salt thereof as an active ingredient, wherein said current ingredient is dissolved or dispersed in the composition comprising solubilizer containing one or more phospholipids, the co-solubilizer comprising a surfactant and a tonicity agent selected from the group consisting of litserina, propylene glycol, sugars, amino acids, proteins, and their salts kombinatsiy.2. A pharmaceutical composition according to claim 1, wherein the active ingredient is an Ara-C-5-elaidic ester kisloty.3. The pharmaceutical composition of claim 1 wherein the solubilizing agent comprises one or more phospholipids are selected from the group consisting of phosphatidyl choline, lyso-phosphatidylcholine, 1, lyso-phosphatidylcholine, 2, phosphatidylglycerol, phosphatidylethanolamine, lyso-phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid, sphingomyelin and cardiolipin, each of which may be present in any form, including saline or desalted, hydrogenated or partially hydrogenated natural, semisynthetic or Synthetic eskie.4. A pharmaceutical composition according to claim 1, wherein the phospholipids are unsaturated natural phospholipids derived from chicken yaits.5. The pharmaceutical composition of claim 1 wherein the co-solubilizer is natriya.6 oleate. A pharmaceutical composition according to claim 1, wherein the isotonic agent is glitserin.7. The pharmaceutical composition of1. Фармацевтическая композиция, включающая в качестве действующего ингредиента производное цитарабина формулы (I):где R1 и R3 являются атомами водорода, и R2 представляет собой C18- или C20- насыщенную или мононенасыщенную ацильную группу, или его фармацевтически приемлемую соль в качестве действующего ингредиентагде указанный действующий ингредиент ра
