Hartmuth C. Kolb;D;Eric Wang;Joseph C. Walsh;Anjana Sinha;Gang Chen;Wei Zhang;Chul Yu;Umesh B. Gangadharmath;Peter J. H. Scott;Changhui Liu;Anna Katrin Szardenings;Vani P. Mocharia;Daniel Kurt Cashion
发明人:
Umesh B. Gangadharmath,Hartmuth C. Kolb,Peter J. H. Scott,Joseph C. Walsh,Wei Zhang,Anna Katrin Szardenings,Anjana Sinha,Gang Chen,Eric Wang,Vani P. Mocharia,Chul Yu,Changhui Liu,Daniel Kurt Cashion,D
申请号：
US12661777
公开号：
US08491869B2
申请日:
2010.03.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
