Umesh B. Gangadharmath,Hartmuth C. Kolb,Peter J.H. Scott,Joseph C. Walsh,Wei Zhang,Anna Katrin Szardenings,Anjana Sinha,Gang Chen,Eric Wang,Vani P. Mocharla,Chul Yu,Changhui Liu,Daniel Kurt Cashion,Dh
申请号：
US13925912
公开号：
US20130302248A1
申请日:
2013.06.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
