Anna Katrin Szardenings,Wei Zhang,Dhanalakshmi Kasi,Anjana Sinha,Umesh B. Gangadharmath,Joseph C. Walsh
申请号：
US13035405
公开号：
US08691187B2
申请日:
2011.02.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
