α-synuclein expression inhibitor

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专利权人:

国立大学法人 東京医科歯科大学;国立研究開発法人医薬基盤・健康・栄養研究所;国立大学法人大阪大学

发明人:

中森 雅之,望月 秀樹,小比賀 聡,横田 隆徳,永田 哲也,笠原 勇矢

申请号：

JP2017560417

公开号：

JP6569920B2

申请日:

2017.01.05

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention can provide a nucleic acid medicine which has a higher effect and a more prolonged effect of inhibiting the expression of ±-synuclein can be provided. Disclosed is the oligonucleotide or a pharmacologically acceptable salt thereof, the oligonucleotide containing at least one nucleoside structure represented by Formula (I): (where each of Base and A are defined substituent or structure), can bind to an ±-synuclein gene, has activity for inhibiting expression of the ±-synuclein gene, and is complementary to the ±-synuclein gene, and the oligonucleotide has a length of twelve to twenty bases.

来源网站：

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