National Institutes of Biomedical Innovation, Health and Nutrition;Osaka University;National University Corporation Tokyo Medical and Dental University
发明人:
申请号：
EP17736000.5
公开号：
EP3415524A4
申请日:
2017.01.05
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention can provide a nucleic acid medicine which has a higher effect and a more prolonged effect of inhibiting the expression of ±-synuclein can be provided. Disclosed is the oligonucleotide or a pharmacologically acceptable salt thereof, the oligonucleotide containing at least one nucleoside structure represented by Formula (I): (where each of Base and A are defined substituent or structure), can bind to an ±-synuclein gene, has activity for inhibiting expression of the ±-synuclein gene, and is complementary to the ±-synuclein gene, and the oligonucleotide has a length of twelve to twenty bases.
