Modulators of alpha-synuclein toxicity

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专利权人:

发明人:

Susan L. Lindquist,Aaron D. Gitler,Anil Cashikar

申请号：

US14666517

公开号：

US09879257B2

申请日:

2015.03.24

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinsons disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.

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中国工程科技知识中心

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