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USE OF C-SRC INHIBITORS IN COMBINATION WITH PYRIMIDILAMINOBENZAMIDE FOR TREATMENT OF LEUKOSIS
专利权人:
НОВАРТИС АГ (CH)
发明人:
Пол У. МАНЛИ (CH)
申请号:
RU2012147511/15
公开号:
RU2012147511A
申请日:
2012.11.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A combination intended for the therapeutic treatment or diagnosis of an animal or human organism, which comprises (a) at least one compound that reduces the activity of protein tyrosine kinase c-Src, and (b) pyrimidylaminobenzamide formula IX: in which R is hydrogen, lower. alkyl ness. alkoxy ness. alkyl, acyloxy lower alkyl, carboxy lower; alkyl ness. alkoxycarbonyl lower alkyl, or phenyl lower. alkyl; R is hydrogen, ness. alkyl optionally substituted with one or more of the same or different R radicals, cycloalkyl, benzcycloalkyl, heterocyclyl, an aryl group, or a mono- or bicyclic heteroaryl group containing 0, 1, 2 or 3 ring nitrogen atoms and 0 or 1 oxygen atom, and 0 or 1 sulfur atom, these groups in each case are unsubstituted or mono- or polysubstituted; and R represents a hydroxy group, lower. alkoxy group, acyloxy group, carboxy group, ness. alkoxycarbonyl, carbamoyl, N-mono- or N, N-disubstituted carbamoyl, amino group, mono- or disubstituted amino group, cycloalkyl, heterocyclyl, aryl group, or a mono- or bicyclic heteroaryl group containing 0, 1, 2 or 3 ring nitrogen atoms and 0 or 1 oxygen atom, and 0 or 1 sulfur atom, these groups are in each case unsubstituted or mono- or polysubstituted; or in which R and R together represent alkylene containing 4, 5 or 6 carbon atoms, optionally mono- or disubstituted lower . alkyl, cycloalkyl, heterocyclyl, phenyl, hydroxy, lower. alkoxy group, amino group, mono - or disubstituted amino group, oxo group, pyridyl, pyrazinyl or pyrimidinyl; benzalkylene containing 4 or 5 carbon atoms1. Комбинация, предназначенная для терапевтического лечения или диагностики организма животного или человека, которая включает (а) по меньшей мере одно соединение, снижающее активность протеинтирозинкиназы c-Src, и (b) пиримидиламинобензамид формулы IX:в которой Rобозначает водород, низш. алкил, низш. алкокси-низш. алкил, ацилокси-низш. алкил, карбокси-низш. алкил, низш. алкоксикарбонил-низш. алкил, или фенил-низш. алкил;Rобозначает в
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