Josef Prassler;Marta Cortes-Cros;Adrian Walmsley;William Leonard Wishart;Ingo Klagge
发明人:
Adrian Walmsley,William Leonard Wishart,Marta Cortes-Cros,Josef Prassler,Ingo Klagge
申请号：
US12514542
公开号：
US08299221B2
申请日:
2007.11.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, and a polynucleotide encoding the binding molecule. The invention also provides an expression vector comprising the polynucleotide, an expression system comprising a polynucleotide capable of producing a binding molecule, as well as an isolated host cell comprising the expression system for producing the binding molecule. The invention also provides for compositions comprising the LINGO binding molecules and the use of binding molecule compositions as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity. The invention further provides for a method of treatment of diseases associated with axonal degeneration and demyelination.
