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IMMUNOCOMPETENT CELL AND EXPRESSION VECTOR EXPRESSING REGULATORY FACTORS OF IMMUNE FUNCTION
专利权人:
YAMAGUCHI UNIVERSITY
发明人:
TAMADA, KOJI,SAKODA, YUKIMI,ADACHI, KEISHI
申请号:
CA3017442
公开号:
CA3017442A1
申请日:
2017.03.15
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present invention addresses the problem of providing: an immunocompetent cell in which regulatory factors of immune function from immunocompetent cells are expressed in the immunocompetent cell, and which combines proliferative capacity, viability, and a capacity for T-cell accumulation and an immune function regulatory factor expression vector for preparing said immunocompetent cell. An immunocompetent cell is prepared which expresses interleukin 7 (IL-7), CCL19, and a cell surface molecule for specifically recognizing cancer antigens. The cell surface molecule for specifically recognizing cancer antigens is preferably a T-cell receptor that specifically recognizes cancer antigens, and the immunocompetent cell is preferably a T-cell.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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