A skull surgical device applicable to a surgical site of skull for performing a surgery is disclosed, comprising a holder unit and a surgical unit which can be driven for transferring its position. The surgical unit is mounted on the holder unit, and comprising an indicator module, a drilling module and an injection module. A light spot projected by the indicator module is used to locate an operation position for performing surgery on the surgical site. By rotating the surgical unit to drive the drilling module and the injection module respectively to move in turn to the operation position and performing drilling and injection operations on the surgical site, therefore, positioning of the drilling and injection operations needs not to be performed in separate two steps, thereby enhancing the operation efficiency in drilling and injection as well as preventing hand trembles from affecting surgery quality during the drilling and injection operations.一種頭骨手術裝置,適用於對一個頭骨的一個手術部位進行手術,並包含一個支架單元,及一個可被驅動而轉換位置的手術單元。該手術單元安裝於該支架單元,並包括一個指示模組、一個鑽孔模組和一個注射模組。利用該指示模組投射出的一個光點來定位出一個可對該手術部位進行手術的作業位置。藉由轉動該手術單元而分別帶動該鑽孔模組及該注射模組輪流移至該作業位置,並對該手術部位進行鑽孔與注藥作業,使得鑽孔與注藥作業不需分兩次定位,因此能提升鑽孔與打藥的作業效率,並能避免鑽孔與注藥時人為的手部抖動而影響手術的品質。10‧‧‧頭骨11‧‧‧老鼠12‧‧‧手術部位13‧‧‧平面14‧‧‧標註符號2‧‧‧支架單元21‧‧‧基座22‧‧‧移動臂23‧‧‧移動機構231‧‧‧縱向軌道232‧‧‧縱移座234‧‧‧橫向軌道235‧‧‧橫移座236‧‧‧橫向驅動器3‧‧‧手術單元30‧‧‧驅動座31‧‧‧指示模組32‧‧‧光點33‧‧‧鑽孔模組331‧‧‧鑽具34‧‧‧注射模組341‧‧‧注藥器4‧‧‧轉動機構A‧‧‧箭頭L‧‧‧直立軸線