Tiotropium salts, process for their preparation and drug formulations containing them

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:

BANHOLZER, ROLF,SIEGER, PETER,PFRENGLE, WALDEMAR

申请号：

DK09153379

公开号：

DK2067779T3

申请日:

2004.10.29

申请国别(地区):

DK

年份:

2013

代理人:

摘要：

Preparation of new tiotropilium salts (1) by subjecting a different tiotropilium salt (2) to anion exchange with an ion source in a solvent. Preparation of new tiotropilium salts of formula (1) by subjecting a different tiotropilium salt of formula (2) to anion exchange with an ion source (Kat-X) in a solvent. [Image] X : anion； Y : anion, different from X, i.e. halo, 1-10C alkyl-sulfonate or -sulfate, or 6-10C arylsulfonate； Kat : cation. An independent claim is also included for new compounds (1) and (2), except where Y/X = bromo, optionally as solvates or hydrates. ACTIVITY : Antiasthmatic. No details of tests for antiasthmatic activity are given. MECHANISM OF ACTION : Anticholinergic.

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