BRASEL, KENNETH ALLAN,FOSTER, STEPHEN,CERRETTI, DOUGLAS PAT,SUN, JILIN,SMOTHERS, JAMES F.,MEHLIN, CHRISTOPHER
申请号:
CA2696761
公开号:
CA2696761C
申请日:
2008.08.19
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Antigen binding proteins that bind to human c-fms protein are provided.Nucleic acids encoding the antigen bindingprotein, vectors, and cells encoding the same are also provided. The antigenbinding proteins can inhibit binding of c-fms to CSF-I,reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.