Mark Stephen Baird,Juma a Raheem Najeem Al-Dulayymi,Cornelia Theunissen,Gani Koza,Seppe Vander Beken,Johan Adriaan Marc Grooten
申请号：
US12988587
公开号：
US08728515B2
申请日:
2009.04.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A compound of formula (I) for use as an adjuvant in vaccination wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5 wherein R5 is alkyl or haloalkyl, and A is S, O or NR6, wherein R6 maybe H or 20 alkyl.
