苯并二氮呯化合物及藥學組成物农业专利-农业学术服务平台

发明人:: OSHIMA, KUNIO,大岛邦生,大島邦生,OSHIYAMA, TAKASHI,押山孝,TAIRA, SHINICHI,平良伸一,MENJO, YASUHIRO,校条康宏,校條康宏,YAMABE, HOKUTO,山边北斗,山邊北斗,MATSUMURA, SHUUJI,松村修二,UEDA, MASATAKA,植田昌孝,KOGA, YASUO,古贺康雄,古賀康

摘要：: The present invention provides a novel benzodiazepine compound that blocks the IKurcurrent or the Kv1.5 channel potently and more selectively than other K+channels. The benzodiazepine compound of the invention is represented by General Formula (1)wherein R1, R2, R3, and R4are each independently hydrogen or lower alkyl； R2and R3may be linked to form lower alkylene； A1is lower alkylene optionally substituted with one or more hydroxy； and R5is group represented bywherein R6and R7are each independently hydrogen or organic group； XAand XBare each independently bond, lower alkylene, etc.本發明提供一種強力且比其它K+通道更具有選擇性地阻斷IKur電流或Kv1.5通道之新穎苯并二氮呯化合物。本發明之苯并二氮呯化合物係以通式(1)表示其中R1、R2、R3及R4各自分別為氫或低碳烷基；R2及R3可鏈接而形成低碳伸烷基；A1為視需要可經以一個或多個羥基取代之低碳伸烷基；及R5為由所表示之基團其中R6及R7各自分別為氫或有機基；XA及XB各自分別為鍵結、低碳伸烷基等。