The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds forin vitro,in situ, andin vivodiagnosis or treatment of mammalian cells, or associated pathological conditions.本發明關於具有抗癌及/或消炎活性之式I之氮雜苯并呋喃基化合物，且尤其關於抑制MEK激酶活性之氮雜苯并呋喃基化合物。本發明提供一種可用於抑制哺乳動物不正常細胞生長或治療過度增生疾病、或治療發炎疾病之組合物及方法。本發明亦關於使用該化合物於體外、原位及體內診斷或治療哺乳動物細胞或相關病理症狀之方法。
