Disclosed are compounds of the FormulaIand pharmaceutically acceptable salts and prodrugs thereor, wherein R1, R2, R7, R8and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.本發明揭示一種式I化合物及其藥學上可接受的鹽和前藥，其中R1，R2，R7，R8和R9，W，X和Y是如說明書中所定義者。此化合物是MEK抑制劑，且可用於治療哺乳動物過度增殖性疾病，像癌症及發炎狀況。本發明也揭示使用該化合物治療哺乳動物過度增殖性疾病的方法及含有該化合物的藥學組成物。
