氮雜苯并噻吩基化合物及使用方法农业专利-农业学术服务平台

发明人:: PRICE, STEPHEN,史蒂芬　普莱斯,史蒂芬　普萊斯,WILLIAMS, KAREN,凯伦　威廉斯,凱倫　威廉斯,SAVY, PASCAL PIERRE,帕斯卡　皮耶　莎菲,DYKE, HAZEL JOAN,海瑟　裘安　戴克,MONTANA, JOHN GARY,约翰　盖瑞　蒙塔那,約翰　蓋瑞　蒙塔那,STANLEY, MARK S.,马克Ｓ　史坦利,史蒂芬普莱斯,史蒂芬普萊斯,凯伦威廉斯,凱倫威廉斯,帕斯卡皮耶莎菲,海瑟裘安戴克,约翰盖瑞蒙塔那,約翰蓋瑞蒙塔那,马克S 史坦利

摘要：: The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds forin vitro,in situ, and in vivodiagnosis or treatment of mammalian cells, or associated pathological conditions.本發明關於具有抗癌及/或消炎活性之式I之氮雜苯并噻吩基化合物，更明確言之，係關於抑制MEK激酶活性之氮雜苯并噻吩基化合物。本發明提供一種可用於抑制哺乳動物不正常細胞生長或治療過度增生疾病、或治療發炎疾病之組合物及方法。本發明亦關於使用該化合物於體外、原位及體內診斷或治療哺乳動物細胞或相關病理症狀之方法。