The invention discloses the excess proliferative disease that is used for the treatment of in the mammal such as the mek inhibitor of cancer and inflammation and inflammatory disease.The invention also discloses the method for using the excess proliferative disease in such compounds for treating mammal and the pharmaceutical composition that comprises such chemical compound.本發明涉及MEK的雜環抑制劑及其使用方法。本發明公開了用於治療哺乳動物中的過度增殖性疾病如癌症和炎症以及炎性病症的MEK抑制劑。本發明還公開了使用這樣的化合物治療哺乳動物中的過度增殖性疾病的方法和包含這樣的化合物的藥物組合物。