BROWN, PAMELA,布朗潘美拉,DAWSON, MICHAEL,道森麦克,道森麥克,SIMONOVIC, MONA,西莫诺维克蒙娜,西莫諾維克蒙娜,BOAKES, STEVEN,布克斯史帝芬,DUPERCHY, ESTHER,杜波奇伊斯特,STANWAY, STEVEN JAMES,史坦威史蒂芬詹姆斯,WILSON, ANTOIN
申请号：
TW104139459
公开号：
TW201625664A
申请日:
2015.11.26
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided. The compound of formula (I) has the structure shown below, where -R6 and -R7 are each together with the carbonyl group and nitrogen alpha to the carbon to which it is attached an amino acid residue, except that R6 together with the carbonyl group and nitrogen alpha to the carbon to which it is attached is not a phenylalanine, leucine or valine residue and/or -R7 together with the carbonyl group and nitrogen alpha to the carbon to which it is attached is not a leucine, iso leucine, phenylalanine, threonine, valine or nor-valine residue, and -T, -A1, -A2, -A3 and -R10 are as discussed in the application: 本發明提供一種式(I)之化合物，及式(I)之化合物在治療方法包括治療細菌感染中的用途。亦提供製備式(I)之化合物之方法。式(I)之化合物具有如下所示之結構，其中-R6及-R7各自與羰基及附接至α位碳的氮一起構成胺基酸殘基，只不過R6與羰基及附接至α位碳的氮一起構成的不是苯丙胺酸、白胺酸或纈胺酸殘基及/或-R7與羰基及附接至α位碳的氮一起構成的不是白胺酸、異白胺酸、苯丙胺酸、蘇胺酸、纈胺酸或正纈胺酸殘基，且-T、-A1、-A2、-A3及-R10如申請案中所論述：
