5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS

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专利权人:

LES LABORATOIRES SERVIER;GALAPAGOS NV

发明人:

BREBION, Franck, Laurent,ALVEY, Luke, Jonathan,AMANTINI, David,DEPREZ, Pierre, Marc, Marie, Joseph,GOSMINI, Romain, Luc, Marie,JARY, Helene, Marie,PEIXOTO, Christophe,VARIN, Marie, Laurence, Claire,DE

申请号：

PH12017501160

公开号：

PH12017501160A1

申请日:

2017.06.20

申请国别(地区):

PH

年份:

2017

代理人:

摘要：

The present invention discloses compounds according to Formula (I), wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.

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