5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS

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专利权人:

LES LABORATOIRES SERVIER;GALAPAGOS NV

发明人:

ALVEY, Luke,AMANTINI, David,BREBION, Franck,DE CEUNINCK, Frédéric,DEPREZ, Pierre,GOSMINI, Romain,JARY, Helène,PEIXOTO, Christophe,POP-BOTEZ, Iuliana,VARIN, Marie

申请号：

TN2017000213

公开号：

TN2017000213A1

申请日:

2015.12.18

申请国别(地区):

TN

年份:

2018

代理人:

摘要：

The present invention discloses compounds according to Formula (1), wherein R, R2, R3a, R3 b,and Cy are as defined herein. The present invention discloses compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.

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中国工程科技知识中心

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http://www.ckcest.cn/home/