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5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
专利权人:
LES LABORATORIES SERVIER;GALAPAGOS NV
发明人:
Franck Laurent Brebion,Luke Jonathan Alvey,David Amantini,Frédéric André De Ceuninck,Pierre Marc Marie Joseph Deprez,Romain Luc Marie Gosmini,Hélène Marie Jary,Christophe Peixoto,Iuliana Ecaterina Pop
申请号:
US15538393
公开号:
US09926281B2
申请日:
2015.12.18
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention discloses compounds according to Formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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