ЛОХХЕД, Скотт (US),ГИЛБЕРТ, Джонатан, Б. (US),БЕРНСТЕЙН, Говард (US),ШАРЕИ, Армон, Р. (US),МУР, Файнола (US)
申请号：
RU2018142039
公开号：
RU2018142039A
申请日:
2017.05.03
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell. In some embodiments, the tolerogenic and/or immunosuppressive immune cell is delivered to an individual and presentation of the antigen induces tolerance and/or suppresses an immune response to the antigen.
