Intracellular delivery of biomolecules to induce tolerance

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专利权人:

SQZ BIOTECHNOLOGIES COMPANY

发明人:

申请号：

IL26267618

公开号：

IL262676D0

申请日:

2018.10.29

申请国别(地区):

IL

年份:

2018

代理人:

摘要：

The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell. In some embodiments, the tolerogenic and/or immunosuppressive immune cell is delivered to an individual and presentation of the antigen induces tolerance and/or suppresses an immune response to the antigen.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/