Gilbert, Jonathan B.,Wang, Bu,Loughhead, Scott,Bernstein, Howard,Sharei, Armon R.,Moore, Finola
申请号：
AU2017259987
公开号：
AU2017259987A1
申请日:
2017.05.03
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.
