INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE

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专利权人:

SQZ BIOTECHNOLOGIES COMPANY

发明人:

GILBERT, Jonathan,WANG, Bu,LOUGHHEAD, Scott,BERNSTEIN, Howard,SHAREI, Armon,MOORE, Finola

申请号：

SG11201809437T

公开号：

SG11201809437TA

申请日:

2017.05.03

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/