1. Claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, wherein: R¹ is hydrogen or C₁₋₆ aliphatic； R¹ᵃ is hydrogen or C₁₋₆ aliphatic； or R¹ and R¹ᵃ are taken together with the carbon atom to which they are attached to form an optionally substituted 3- to 6-membered carbocyclic spiro ring； each R² is independently hydrogen, -halogen, -OR, -NO₂,-Cn, - Mr, - n (R) 8322,-C (O) R, -C (O) OR, -S (O) R, -S (O) ₂R, -C (O) N (R) ₂,-SO N (R)-OC (O) R, -N (R) C (O) R, -N (R) C (O) OR, -N (R) SO₂R, -OC (O) N (R) ₂,or an optionally substituted group selected from the group consisting of aliphatic C₁₋₆ and 3- to 6-membered saturated or partially unsaturated monocyclic carbocyclyl； R³ is hydrogen or optionally substituted aliphatic C₁₋₆； R⁴ is hydrogen, a natural or unnatural amino acid side chain group, or an optionally substituted group selected from the group consisting of C₁₋₆ aliphatic, 3- to 7-membered saturated or partially unsaturated monocyclic carbocyclyl, and phenyl；or R³ and R⁴ are taken together with the carbon atom attached to R⁴ and the nitrogen atom attached to R³ to form an optionally substituted 3- to 6-membered heterocyclyl ring having 0-1 additional heteroatoms selected from oxygen, nitrogen or sulfur； R⁵ is hydrogen or optionally substituted aliphatic C₁₋₆； or R⁴ and R⁵ are taken together with the carbon atom to which they are attached to form an optionally substituted ring selected from a 3- to 6-membered heterocyclic spiro ring having 1-2 hetero atoms selected from oxygen,nitrogen or sulfur and a 3-6 membered saturated or partially unsaturated monocyclic spiro carbocyclic ring； L is a covalent bond or a straight or branched hydrocarbon chain, saturated or unsaturated bivalent C₁₋₁₀, where one, two or three methylene units of L are optionally and independently replaced by -Cy-,- that is...-So...-SO₂-,-C (O) --C (O) N (R) -- yes.-N (R) --That's it.-OC (o)..-N (R) C (O) --N (R) SO -o -SO N (R) -Among them, each ring is a selective biva
