HARRIMAN, Geraldine,MASSE, Craig,HARWOOD, James,BHAT, Sathesh,GREENWOOD, Jeremy
申请号：
ES12848361
公开号：
ES2665580T3
申请日:
2012.11.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula II: ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen or C1-4 aliphatic hydrocarbon, optionally substituted with one or more halogens, -OR, -SR, - N (R) 2, -N (R) C (O) R, -C (O) N (R) 2, -N (R) C (O) N (R) 2, -N (R) C (O) OR, -OC (O) N (R) 2, -N (R) SO2R, -SO2N (R) 2, - C (O) R, -C (O) OR, -OC (O) R , -S (O) R or -SO2R； R2 is Hy, where Hy is selected from a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1- 4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen or sulfur； each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic hydrocarbon, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring； a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen or sulfur； R3 is hydrogen, halogen, -CN, -OR, -SR, -N (R) 2, - N (R) C (O) R, -C (O) N (R) 2, -N (R) C (O) N (R) 2, -N (R) C (O) OR, -OC (O) N (R) 2, -N (R) SO2R, -SO2N (R) 2, -C (O) R, - C (O) OR, -OC (O) R, -S (O) R, -SO2R, -B (OH) 2, or an optionally substituted ring selected from 5-6 membered phenyl or heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur； R4 is an optionally substituted phenyl or naphthyl ring； each of R5 and R5 'is independently -R, -OR, -SR, -N (R) 2, -
