Cell-permeable endostatin recombinant protein, a polynucleotide encoding the same, and an anti-cancer preparation containing the same as an active component
Daewoong Jo,Jong Min Lee,Kyoungho Park,Minh Tam Duong
申请号：
US12936334
公开号：
US08586544B2
申请日:
2009.04.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a cell-permeable endostatin recombinant protein in which a macromolecule transduction domain (MTD) is fused to an angiogenesis inhibitor (angiogenesis inhibitor) endostatin a polynucleotide encoding the cell-permeable endostatin recombinant protein an expression vector for the cell-permeable endostatin recombinant protein and a pharmacological composition for an anti-cancer preparation with improved inhibitory activity against angiogenesis in cancer, which contains the cell-permeable endostatin recombinant protein as an active component. The cell-permeable endostatin recombinant protein according to the present invention can block the formation of microvessels and inhibit the migration, proliferation, penetration, tube formation and the like of vascular endothelial cells present in tumor tissue by introducing the angiogenesis inhibitor endostatin into the cell with high efficiency, and it exhibits outstanding anti-cancer activity and so can be used as an anti-cancer drug against various cancers.
