DERIVES DE 10-(DI(PHENYL)METHYL)-4-HYDROXY-8,9,9A,10-TETRAHYDRO-7H-PYRROLO[1 ',2':4,5]PYRAZI NO[1,2-B]PYRIDAZINE-3,5-DIONE ET COMPOSES APPARENTES UTILISES EN TANT QU'INHIBITEURS DE LA REPLICATION D'ORTHOMYXOVIRUS POUR LE TRAITEMENT DE LA GRIPPE
DAUPHINAIS, MAXIME,JAIN, RAMA,KOESTER, DENNIS CHRISTOFER,MANNING, JAMES R.,MARX, VANESSA,POON, DANIEL,WAN, LIFENG,WANG, XIAOJING MICHAEL,YIFRU, AREGAHEGN,ZHAO, QIAN
申请号：
CA3092544
公开号：
CA3092544A1
申请日:
2019.02.26
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure refers to 10-(di(phenyl)methyl)-4- hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1'；2':4,5]pyrazino[1,2- b]pyridazine-3,5-dione derivatives and related compounds of Formula (A) as inhibitors of the orthomyxovirus replication for treating influenza.(Formula A) (A) A preferred specific compound is e.g. (9aR, 10S)-10-((S)-(4- fluorophenyl)(3-(trifluoromethyl)phenyl)methyl)-4-hydroxy-8,9,9a,10- tetrahydro-7H-pyrrolo[1'；2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione (example 1).
