10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza

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专利权人:

Novartis AG

发明人:

DAUPHINAIS, Maxime,JAIN, Rama,KOESTER, Dennis Christofer,MANNING, James R.,MARX, Vanessa,POON, Daniel,WAN, Lifeng,WANG, Xiaojing Michael,YIFRU, Aregahegn,ZHAO, Qian

申请号：

AU2019227250

公开号：

AU2019227250A1

申请日:

2019.02.26

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present disclosure refers to 10-(di(phenyl)methyl)-4- hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1'；2':4,5]pyrazino[1,2- b]pyridazine-3,5-dione derivatives and related compounds of Formula (A) as inhibitors of the orthomyxovirus replication for treating influenza.(Formula A) (A) A preferred specific compound is e.g. (9aR, 10S)-10-((S)-(4- fluorophenyl)(3-(trifluoromethyl)phenyl)methyl)-4-hydroxy-8,9,9a,10- tetrahydro-7H-pyrrolo[1'；2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione (example 1).

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