10-(DI(PHENYL)METHYL)-4-HYDROXY-8,9,9A,10-TETRAHYDRO-7H-PYRROLO[1 ',2':4,5]PYRAZINO[1,2-B]PYRIDAZINE-3,5-DIONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE ORTHOMYXOVIRUS REPLICATION FOR TREATING INFLUENZA
DAUPHINAIS, Maxime,JAIN, Rama,KOESTER, Dennis Christofer,MANNING, James R.,MARX, Vanessa,POON, Daniel,WAN, Lifeng,WANG, Xiaojing Michael,YIFRU, Aregahegn,ZHAO, Qian
申请号：
SG11202007718S
公开号：
SG11202007718SA
申请日:
2019.02.26
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
The present disclosure refers to 10-(di(phenyl)methyl)-4- hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1'；2':4,5]pyrazino[1,2- b]pyridazine-3,5-dione derivatives and related compounds of Formula (A) as inhibitors of the orthomyxovirus replication for treating influenza.(Formula A) (A) A preferred specific compound is e.g. (9aR, 10S)-10-((S)-(4- fluorophenyl)(3-(trifluoromethyl)phenyl)methyl)-4-hydroxy-8,9,9a,10- tetrahydro-7H-pyrrolo[1'；2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione (example 1).
