ПЕРО Джозеф Е. (US),ЛЕМАН Ханна Д. Дж. Ф. (US),КЕЛЛИ Майкл Дж. III (US),ЧЖАО Ляньинь (US),РОССИ Майкл А. (US),ЛИ Даньсу (US),ГИЛБЕРТ Кевин Ф. (US),УОЛКЕНБЕРГ Скотт (US),МАЛХИРН Джеймс (US),ЛЕЙТОН Марк
申请号：
RU2015119635
公开号：
RU2015119635A
申请日:
2013.10.23
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A compound of formula or a pharmaceutically acceptable salt thereof with a selective activity as blockers of sodium ion channel Na1.7: Formula A, wherein: a) Ryavlyaetsya -H, Calkilom, alkoxy, -CN or halo b) "Het" is 6-membered heteroaryl moiety containing up to three heteroatoms selected from N, S and O, linked via any ring atom of the aryl moiety, available for binding, and optionally substituted with one or more "ring system substituents" which are alkyl, aryl, heteroaryl, , aralkyl, alkylaryl , Aralkenyl, heteroaralkyl, alkylheteroaryl, heteroaralkenyl, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, alkylsulfinyl, arylsulfinyl, geteroarilsulfinil, alkylthio , arylthio, heteroarylthio, aralkylthio, geteroaralkiltio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, RRN-, RRN-alkyl-, RRNC (O) - and RRNSO-, wherein each of R Ryavlyaetsya independently: hydrogen, alkyl, aryl and aralkyl and c) Rya S THE aryl radical with one or more ring system substituents which are independently for each occurrence: (i) heterocyclenyl (Ii) tseterotsiklil (Iii) or geteropirazinil (Iv) aminoalkil.2. A compound according to Claim. 1 or a salt thereof, wherein Ryavlyaetsya aryl residue with at least one "substituent koltsevoysistemy", which is a C-heterocycloalkyl residue, containing up to three geteroatomov.3. A compound of formula A with selective activity as blockers of sodium ion channel Na1.7: Formula A, wherein: a) Ryavlyaetsya -H, Calkilom, alkoxy, -CN or halo b) "Het" is a moiety of the formula: wherein one of
