Heterocyclic compounds derived from etinilo, mGluR5 allosteric modulators； Preparation Process； Pharmaceutical composition； use in the Prevention or treatment of Cognitive diseases, Schizophrenia, Autism or Fragile X Syndrome.

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

JAESCHKE, GEORG,LINDEMANN, LOTHAR,RICCI, ANTONIO,RUEHER, DANIEL,VIEIRA, ERIC,STADLER, HEINZ

申请号：

CL2014000819

公开号：

CL2014000819A1

申请日:

2014.04.03

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

The present invention relates to ethynyl derivatives of formula I wherein U, V, Y, R1, R2, R2&prime；, R3, R3&prime； and R8 are described herein. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).COMPUESTOS HETEROCICLICOS DERIVADOS DE ETINILO-PIRIDINA(PIRIMIDINA), MODULADORES ALOSTERICOS DE MGLUR5； PROCESO DE PREPARACION； COMPOSICION FARMACEUTICA； USO EN LA PREVENCION O EL TRATAMIENTO DE ESQUIZOFRENIA, ENFERMEDADES COGNITIVAS, SINDROME DE LA X FRAGIL O AUTISMO.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/